Pain pathways

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Pain pathways and transmission.

Pain has been a major concern of humankind since the ancient times, and it remains one of the most important subjects of all health care professionals. Despite the obvious overwhelming clinical importance, the major advances in its diagnosis and therapy have been made only recently. "How do the sensory apparatus of the body and system of signal transmission relate to pain of peripheral origin?"...

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Pain pathways in orthopaedic practice.

DESPITE Steindler's (1959) admirable lectures on the subject, pain in orthopiedic practice remains a difficult problem. To some extent the difficulty is exaggerated by the adoption of diagnoses based on pathological processes which are insusceptible of proof-diagnoses for which it is impossible to establish an association between symptoms and their alleged origin, let alone a direct causal link...

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Probing pain pathways with light

We have witnessed an accelerated growth of photonics technologies in recent years to enable not only monitoring the activity of specific neurons, while animals are performing certain types of behavior, but also testing whether specific cells, circuits, and regions are sufficient or necessary for initiating, maintaining, or altering this or that behavior. Compared to other sensory systems, howev...

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Understanding LTP in pain pathways

Long-term potentiation (LTP) at synapses of nociceptive nerve fibres is a proposed cellular mechanism underlying some forms of hyperalgesia. In this review fundamental properties of LTP in nociceptive pathways are described. The following topics are specifically addressed: A concise definition of LTP is given and a differentiation is made between LTP and "central sensitisation". How to (and how...

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Idiopathic pain disorders--pathways of vulnerability.

Idiopathic pain disorders (IPDs) consist of such conditions as temporomandibular joint disorders (TMJD), fibromyalgia syndrome (FMS), irritable bowel syndrome (IBS), chronic headaches, interstitial cystitis, chronic pelvic pain, chronic tinnitus, whiplash-associated disorders, and vulvar vestibulitis (VVS). IPDs commonly aggregate as ‘‘comorbid’’ conditions that are characterized by a complaint...

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ژورنال

عنوان ژورنال: Nature

سال: 1995

ISSN: 0028-0836,1476-4687

DOI: 10.1038/378658b0